What are the Potential Side Effects of PARP Inhibition?
While PARP inhibitors offer a promising approach for cancer treatment, they can also cause adverse effects. Common side effects include nausea, fatigue, and hematological toxicities such as anemia and thrombocytopenia. Long-term use may lead to the development of resistance, as cancer cells adapt by restoring homologous recombination or finding alternative repair pathways. Therefore, ongoing research is focused on understanding resistance mechanisms and optimizing combination therapies.
