PARP is involved in various forms of cell death, including apoptosis and necroptosis. Overactivation of PARP, such as during extensive DNA damage, can lead to a depletion of cellular NAD+ and ATP, driving cells towards necrosis. Alternatively, PARP can facilitate apoptosis by modulating apoptotic signaling pathways. This dual role highlights the complex interplay between DNA damage response and cell fate determination.
