Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair and programmed cell death. The most studied member of this family is PARP-1, which plays a critical role in the repair of single-strand DNA breaks. PARP detects DNA damage and signals for repair by attaching ADP-ribose units to itself and other nuclear proteins, a process known as PARylation.
