What Are the Challenges Associated with Agonistic Antibodies?
Despite their potential, the use of agonistic antibodies is not without challenges. One major issue is the risk of off-target effects, where the antibody activates unintended receptors, leading to adverse effects. Additionally, the immune system may recognize these engineered antibodies as foreign, prompting an immune response against them. Ensuring the stability and bioavailability of agonistic antibodies in the body is another significant hurdle. Researchers are actively working on strategies to mitigate these challenges, such as engineering antibodies with enhanced specificity and reduced immunogenicity.
