How Does Insufficient Apoptosis Affect Development and Aging?
During development, apoptosis is essential for sculpting tissues and organs by removing excess cells. Insufficient apoptosis can disrupt these processes, leading to developmental abnormalities. Additionally, as organisms age, the accumulation of cells that have evaded apoptosis can contribute to tissue dysfunction and age-related diseases. The failure to eliminate senescent cells can result in chronic inflammation and tissue damage, a phenomenon often referred to as "inflammaging."
