Neuroinflammation is a common feature in neurodegenerative diseases and involves the activation of glial cells such as microglia and astrocytes. Chronic inflammation can: - Release pro-inflammatory cytokines and chemokines, creating a toxic environment for neurons. - Activate microglia, leading to phagocytosis of healthy neurons. - Disrupt the blood-brain barrier, allowing peripheral immune cells to infiltrate the brain.
