What Are the Implications of DNA Fragmentation in Disease?
Abnormal DNA fragmentation can be associated with various diseases. For instance, excessive fragmentation can lead to infertility issues in men, as it affects sperm DNA integrity. In cancer, dysregulated apoptosis and DNA fragmentation can contribute to unchecked cell proliferation. Furthermore, neurodegenerative diseases such as Alzheimer's are linked to increased DNA fragmentation in neurons.
