Death receptors are transmembrane proteins characterized by an intracellular death domain that triggers apoptosis when activated. They respond to specific ligands, such as FasL, TNF-α, and TRAIL, to initiate a signaling cascade that leads to cell death. Prominent death receptors include Fas receptor (CD95), TNF receptor 1 (TNFR1), and TRAIL receptors (DR4 and DR5).
