What Happens if Fas Receptor Signaling is Impaired?
Impairment in Fas receptor signaling can lead to various pathological conditions. For instance, mutations or defects in the Fas receptor or FasL can result in autoimmune lymphoproliferative syndrome (ALPS), a disorder characterized by the accumulation of lymphocytes due to defective apoptosis. Furthermore, impaired Fas signaling is associated with the development and progression of certain cancers, as tumor cells may evade apoptosis by downregulating Fas expression or disrupting the signaling pathway.
