The expression of the Fas receptor is tightly regulated at multiple levels, including transcriptional and post-translational modifications. Transcription factors such as NF-κB and p53 can enhance Fas expression in response to various stimuli, including stress and DNA damage. Additionally, the receptor can be modulated by glycosylation and other post-translational modifications that affect its localization and stability on the cell surface, influencing its ability to interact with FasL.
