What Cellular Mechanisms are Involved in Preterm Labor?
Several cellular mechanisms are crucial in the initiation of preterm labor. One of the primary processes involves the extracellular matrix (ECM) remodeling of the cervix. The ECM is degraded by matrix metalloproteinases (MMPs), which are enzymes that break down collagen and other ECM components, leading to cervical ripening and dilation.
Another important cellular mechanism is the activation of inflammatory pathways. Pro-inflammatory cytokines like IL-1, IL-6, and TNF-α are released, which can induce the production of prostaglandins and other molecules that stimulate uterine contractions. These inflammatory responses are often triggered by infections or stress conditions.
