How do Cell Signaling Pathways Contribute to Preterm Labor?
Cell signaling pathways are integral to the process of labor. The NF-κB pathway is one of the key regulators of inflammation during preterm labor. Activation of NF-κB leads to the transcription of genes encoding pro-inflammatory cytokines, chemokines, and MMPs, which contribute to cervical ripening and uterine contractions.
The MAPK/ERK pathway is another signaling cascade implicated in preterm labor. This pathway can be activated by stress signals and inflammatory cytokines, leading to the production of prostaglandins and other labor-inducing molecules.
