What are Some Disorders Associated with ER Dysfunction?
ER dysfunction can lead to several diseases and disorders, including:
ER stress: Accumulation of unfolded or misfolded proteins in the ER lumen can trigger ER stress, leading to cell death if not resolved. This is implicated in diseases such as diabetes, neurodegeneration, and cancer. Lipid metabolism disorders: Aberrations in lipid synthesis and metabolism can result in conditions like fatty liver disease and atherosclerosis. Calcium homeostasis disorders: Disruption in calcium storage and signaling can affect muscle function and is associated with diseases like cardiac arrhythmias and muscle dystrophies.
