proteostasis

How Does the Ubiquitin-Proteasome System Work?

The ubiquitin-proteasome system is a major pathway for protein degradation in cells. Proteins destined for degradation are tagged with ubiquitin, a small regulatory protein, through a series of enzymatic reactions involving ubiquitin-activating, conjugating, and ligase enzymes. The ubiquitin-tagged proteins are then recognized and degraded by the proteasome, a large protease complex, into small peptides, recycling amino acids for new protein synthesis.

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