How Do Intrinsic and Extrinsic Pathways Contribute?
The intrinsic pathway is primarily regulated by the mitochondria and involves the release of cytochrome c, which activates caspases, leading to cell death. The extrinsic pathway is initiated by the binding of death ligands to their corresponding death receptors on the cell surface, triggering a cascade that also activates caspases. Both pathways can be dysregulated, contributing to excessive apoptosis in conditions such as neurodegenerative diseases and ischemic injuries.
