RTK activity is tightly regulated at multiple levels to ensure proper cellular responses. Mechanisms of regulation include: - Ligand availability and binding - Dimerization and autophosphorylation - Interaction with regulatory proteins such as phosphatases - Receptor internalization and degradation through endocytosis - Feedback inhibition through downstream signaling components
These mechanisms ensure that RTK signaling is transient and appropriately modulated to prevent aberrant cellular responses.
