What are the consequences of dysregulated cell cycle?
Dysregulation of the cell cycle can lead to uncontrolled cell proliferation, a hallmark of cancer. Mutations in genes encoding cyclins, CDKs, or checkpoint proteins can bypass normal regulatory mechanisms, allowing cells to divide uncontrollably. For instance, mutations in the tumor suppressor p53, which plays a crucial role in DNA damage response, can lead to the evasion of cell cycle checkpoints, contributing to tumorigenesis.
