helen s bateup - Cell Biology

Author Information

Helen S. Bateup is a prominent researcher affiliated with the Department of Molecular and Cell Biology and the Helen Wills Neuroscience Institute at the University of California, Berkeley. Her research focuses primarily on the intersection of molecular and cellular biology with neuroscience, contributing significantly to the understanding of neuropsychiatric diseases and neurodevelopmental disorders. Helen S. Bateup's work is characterized by a deep investigation into genetic models and cellular mechanisms underlying brain function and dysfunction.

Research Contributions

Helen S. Bateup has made substantial contributions to the field of neuroscience, particularly in understanding the molecular pathways and genetic factors involved in neurodevelopmental and neuropsychiatric disorders. Her recent work includes exploring the effects of Tsc1 loss in neurons, which impacts motor learning and endocannabinoid signaling, as well as developing genetic models to study dopamine neuron subpopulations. Bateup's research also extends to innovative methodologies, such as prime editing for generating pluripotent stem cell models, and the use of human brain organoids to model somatic mutations associated with neurodevelopmental disorders. Her studies are pivotal in uncovering the cellular underpinnings of diseases like Tuberous Sclerosis Complex and autism spectrum disorders.

Aliases

Helen S. Bateup is also known by the aliases Helen Bateup and Helen S Bateup, which are frequently used in her scholarly publications and professional affiliations.

Publication and Citation Metrics

Metric	Value
Total Papers	51
Total Citations	3402
H-index	23

Publications:

Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning.

DOI: 10.1016/j.celrep.2022.110563

Year: 2022

Highly efficient generation of isogenic pluripotent stem cell models using prime editing

DOI: 10.1101/2022.02.15.480601

Year: 2022

Generation of a DAT-P2A-Flpo mouse line for intersectional genetic targeting of dopamine neuron subpopulations

DOI: 10.1016/j.celrep.2021.109123

Year: 2021

The Convergence of Two Signaling Pathways Within the Striatum Reveals Potential Mechanisms of Neuropsychiatric Disease

DOI: 10.1016/j.biopsych.2021.03.019

Year: 2021

A multimodal cell census and atlas of the mammalian primary motor cortex

DOI: 10.1038/s41586-021-03950-0

Year: 2021

Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex

DOI: 10.1101/2021.07.21.453275

Year: 2021

Modeling Somatic Mutations Associated With Neurodevelopmental Disorders in Human Brain Organoids

DOI: 10.3389/fnmol.2021.787243

Year: 2021

Transient Food Insecurity During the Juvenile-Adolescent Period Affects Adult Weight, Cognitive Flexibility, and Dopamine Neurobiology

DOI: 10.2139/ssrn.3991074

Year: 2021

Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning

DOI: 10.1016/j.celrep.2021.109511

Year: 2021

Dopaminergic Dysregulation in Syndromic Autism Spectrum Disorders: Insights From Genetic Mouse Models

DOI: 10.3389/fncir.2021.700968

Year: 2021

How Are Death Receptors Involved in Disease?

What are the Consequences of Necrosis?

What are Microfilaments?

How Are Antibody-Based Therapies Utilized?

What are the Functions of NADPH and Ribose-5-Phosphate?

How Does Gene Therapy Work?

How is it Studied?

What Role Does Insulin Play in PCOS?

What is the Role of Autophagy in Proteostasis?

What are the Key Components of Growth Signaling Pathways?

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