Topoisomerase I - Cell Biology

Relevant Publications

Sulforaphane Induces Transient Reactive Oxygen Species-Mediated DNA Damage in HeLa Cells.

Issue Release: 2025

Mutations in Tyrosyl-DNA Phosphodiesterase 2 suppress top-2 induced chromosome segregation defects during C. elegans spermatogenesis.

Issue Release: 2024

Topoisomerase I is an evolutionarily conserved key regulator for satellite DNA transcription.

Issue Release: 2024

3D layered co-culture model enhances Trastuzumab Deruxtecan sensitivity and reveals the combined effect with G007-LK in HER2-positive non-small cell lung cancer.

Issue Release: 2024

Biotechnological approaches for the production of camptothecin.

Issue Release: 2024

Direct and indirect toxicity mechanisms of the natural insecticide azadirachtin based on in-silico interactions with tubulin, topoisomerase and DNA.

Issue Release: 2024

Safety, Efficacy, and Pharmacokinetics of SHR-A1811, a Human Epidermal Growth Factor Receptor 2-Directed Antibody-Drug Conjugate, in Human Epidermal Growth Factor Receptor 2-Expressing or Mutated Advanced Solid Tumors: A Global Phase I Trial.

Issue Release: 2024

Levels of anti-topoisomerase I antibody correlated with short onset of cardiopulmonary involvement in Thai systemic sclerosis patients.

Issue Release: 2024

Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies.

Issue Release: 2024

TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks.

Issue Release: 2024

Synergistic Nanomedicine Delivering Topoisomerase I Toxin (SN-38) and Inhibitors of Polynucleotide Kinase 3\'-Phosphatase (PNKP) for Enhanced Treatment of Colorectal Cancer.

Issue Release: 2024

DB-1314, a novel DLL3-targeting ADC with DNA topoisomerase I inhibitor, exhibits promising safety profile and therapeutic efficacy in preclinical small cell lung cancer models.

Issue Release: 2024

Quantitative determination of liposomal irinotecan and SN-38 concentrations in plasma samples from children with solid tumors: Use of a cryoprotectant solution to enhance liposome stability.

Issue Release: 2024

Novel antibody-drug conjugates based on DXd-ADC technology.

Issue Release: 2024

RNA interacts with topoisomerase I to adjust DNA topology.

Issue Release: 2024

Identification of 7-aminourea or 7-aminothiourea derivatives of camptothecin as selective topoisomerase I inhibitors with anti-colorectal cancer activities.

Issue Release: 2024

Dual inhibition of topoisomerase II and microtubule of podophyllotoxin derivative 5p overcomes cancer multidrug resistance.

Issue Release: 2024

Development of a multivariable prediction model for progression of systemic sclerosis-associated interstitial lung disease.

Issue Release: 2024

Pathogenic role of anti-nuclear autoantibodies in systemic sclerosis: Insights from other rheumatic diseases.

Issue Release: 2024

Biomimetic modification of macrophage membrane-coated prussian blue nanoparticles loaded with SN-38 to treat colorectal cancer by photothermal-chemotherapy.

Issue Release: 2024

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Topoisomerase I - Cell Biology

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